[T and B lymphocyte function of patients with infectious complications after surgery for congenital heart defects]. / Sostoianie T- i B-limfotsitov u bol'nykh s infektsionnymi oslozhneniiami posle operatsii po povodu vrozhdennykh porokov serdtsa.

The parameters of T- and B-lymphocyte system were studied in 65 patients with congenital heart defects aged from 2 to 31 years with infectious complications after operation. The investigation was performed before operation and in the course of the postoperative period. Patients with infectious complications were shown to have more considerable suppression of cell and humoral immunity before operation than those without infectious complications. The parameters concerned were found to be distinctly decreased in the early postoperative period. Two weeks after operation no normalization of the immune parameters were noted.

[Metabolism of fatty acids in the healthy myocardium and in ischemia]. / Metabolizm zhirnykh kislot v miokarde v norme i pri ishemii (obzor)

Data on absorption and consumption in heart tissue of free and ester-bound fatty acids from blood lipids are discussed. Preferential utilization of individual fatty acids in heart tissue from blood lipids is considered. Dependence of fatty acid metabolism on the activity of tricarboxylic acid cycle, interrelationship between metabolism of endogenous and exogenous fatty acids in heart muscle are considered. The data are analyzed on pathways of exogenous fatty acids turnover in tissues, their conversion into endogenous fatty acids, specific for individual tissue, cells and their organelles. Development of syndrome of unsaturated fatty acids deficiency, induced by incomplete fatty diet, is discussed. Metabolism of fatty acids in heart under conditions of oxygen deficiency is considered. The data are reviewed on the effects of hypoxia on metabolism of fatty acids in myocardium. Carbohydrate and fatty acid consumption in heart muscle, typical alterations in fatty acid incorporation into heart lipids, effect of fatty acids excess on functioning of sarcoplasmic reticulum and mitochondrial membranes are discussed.

[Effect of nerobolil on higher fatty acid metabolism in the rat liver normally and in disordered protein metabolism]. / Vliianie nerobolila na metabolizm vysshikh zhirnykh kislot v pecheni u krys v norme i pri narushenii belkovogo obmena.

Metabolism of fatty acids in rat liver tissue and content of albumin in blood of control rats as well as in the animals with impaired protein metabolism as a result of thermic trauma were studied under conditions of nerobolyl treatment (5 mg per kg of body mass within a day) of different duration. After daily administration of the drug (within 13 days) into control rats and into the animals with burns, content of oleic and linoleic acids was decreased in liver tissue but the content of 5,8,11-eicosatrienic acid and total monoenic acids with uneven amount of carbon atoms was increased with simultaneous decrease in albumin concentration in blood. Metabolism of fatty acids was altered only slightly in liver tissue of healthy animals after nerobolyl administration within three weeks (with an interval for 3-4 days); under conditions of the thermic trauma nerobolyl normalized the fatty acids metabolism in liver tissue and increased the albumin content in blood.

[Experimental aortic stenosis, its subsequent correction and the activity of oxidative enzymes in the myocardium]. / Eksperimental'nyi stenoz aorty, ego posleduiushchee ustranenie i aktivnost' okislitel'nykh fermentov v serdechnoi myshtse

The activity of the respiratory enzymes of myocardial mitochondria--succinatedehydrogenase and cytochromixidase--was studied in experimentally induced aortic stenosis and after its elimination in 98 mongrel dogs. The observation period of stenosis was 1, 15, 30 and 60 days, and after its elimination--1, 7, 15 and 30 days. The activity of the enzymes in question was found to grow after the production of aortic stenosis. The highest level of their enzymatic activity was observed on the 15th day after the induction of stenosis. By the 30th and 60th day the enzymatic activity underwent some decrease, although it persisted on a level above the initial. The activity of succinatedehydrogenase fell sharper. After the elimination of the stenosis the activity of both enzymes decreased, and by the 7th day it was below the initial level. By the 15th day after the removal of the ligature from the aorta the activity of both enzymes corresponded to the initial values and did not change further till the end of the 1st month. The dynamics of the activity of succinatedehydrogenase and cytochromixidase after an experimentally induced aortic stenosis and its subsequent elimination seems to depend on the nature of the changes in the function of the heart muscle performed under such experimental pathology, and on the degree of coronary flow enhancement.